4P59

HER3 extracellular domain in complex with Fab fragment of MOR09825

Summary for 4P59

• Entry DOI: 10.2210/pdb4p59/pdb
• Descriptor: Receptor tyrosine-protein kinase erbB-3, MOR09825 Fab fragment heavy chain, MOR09825 Fab fragment light chain, ... (6 entities in total)
• Functional Keywords: her3 receptor, therapeutic antibody, fab fragment, anti-her3, signaling protein, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 119419.80

Authors

Sprague, E.R. (deposition date: 2014-03-15, release date: 2014-04-16, Last modification date: 2023-09-27)

• Primary citation: Garner, A.P.,Bialucha, C.U.,Sprague, E.R.,Garrett, J.T.,Sheng, Q.,Li, S.,Sineshchekova, O.,Saxena, P.,Sutton, C.R.,Chen, D.,Chen, Y.,Wang, H.,Liang, J.,Das, R.,Mosher, R.,Gu, J.,Huang, A.,Haubst, N.,Zehetmeier, C.,Haberl, M.,Elis, W.,Kunz, C.,Heidt, A.B.,Herlihy, K.,Murtie, J.,Schuller, A.,Arteaga, C.L.,Sellers, W.R.,Ettenberg, S.A.; An antibody that locks HER3 in the inactive conformation inhibits tumor growth driven by HER2 or neuregulin.; Cancer Res., 73:6024-6035, 2013; PubMed: 23928993; DOI: 10.1158/0008-5472.CAN-13-1198

Experimental method

X-RAY DIFFRACTION (3.4 Å)