4P0W

Human farnesyl diphosphate synthase in complex with Arenarone and zoledronate

Summary for 4P0W

Entry DOI	10.2210/pdb4p0w/pdb
Descriptor	Farnesyl pyrophosphate synthase, 2-{[(1S,2R,4aS,8aR)-1,2,4a-trimethyl-5-methylidenedecahydronaphthalen-1-yl]methyl}cyclohexa-2,5-diene-1,4-dione, ZOLEDRONIC ACID, ... (5 entities in total)
Functional Keywords	fpps, inhibitor, complex, prenyl synthase, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	40687.14
Authors	Liu, Y.L.,Oldfield, E. (deposition date: 2014-02-23, release date: 2014-07-02, Last modification date: 2023-12-27)
Primary citation	Liu, Y.L.,Lindert, S.,Zhu, W.,Wang, K.,McCammon, J.A.,Oldfield, E. Taxodione and arenarone inhibit farnesyl diphosphate synthase by binding to the isopentenyl diphosphate site. Proc.Natl.Acad.Sci.USA, 111:E2530-E2539, 2014 Cited by PubMed: 24927548 DOI: 10.1073/pnas.1409061111 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.406 Å)

Structure validation