4O77

Crystal structure of the first bromodomain of human BRD4 in complex with SB 202190

Summary for 4O77

Entry DOI	10.2210/pdb4o77/pdb
Related	4O70 4O71 4O72 4O73 4O74 4O75 4O76 4O78 4O7A 4O7B 4O7C 4O7E 4O7F
Descriptor	Bromodomain-containing protein 4, 4-[4-(4-fluorophenyl)-5-(pyridin-4-yl)-1H-imidazol-2-yl]phenol (3 entities in total)
Functional Keywords	bromodomain, cap, hunk1, mcap, protein binding-inhibitor complex, mitotic chromosome associated protein, cell cycle, inhibitor, transcription-inhibitor complex, transcription/inhibitor
Biological source	Homo sapiens (human)
Cellular location	Nucleus: O60885
Total number of polymer chains	2
Total formula weight	30861.45
Authors	Ember, S.W.,Zhu, J.-Y.,Watts, C.,Schonbrunn, E. (deposition date: 2013-12-24, release date: 2014-03-05, Last modification date: 2023-09-20)
Primary citation	Ember, S.W.,Zhu, J.Y.,Olesen, S.H.,Martin, M.P.,Becker, A.,Berndt, N.,Georg, G.I.,Schonbrunn, E. Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors. Acs Chem.Biol., 9:1160-1171, 2014 Cited by PubMed: 24568369 DOI: 10.1021/cb500072z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation