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4O78

Crystal structure of the first bromodomain of human BRD4 in complex with GW612286X

Summary for 4O78
Entry DOI10.2210/pdb4o78/pdb
Related4O70 4O71 4O72 4O73 4O74 4O75 4O76 4O77 4O7A 4O7B 4O7C 4O7E 4O7F
DescriptorBromodomain-containing protein 4, N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine, 1,2-ETHANEDIOL, ... (6 entities in total)
Functional Keywordsbromodomain, cap, hunk1, mcap, protein binding-inhibitor complex, mitotic chromosome associated protein, cell cycle, inhibitor, transcription-inhibitor complex, transcription/inhibitor
Biological sourceHomo sapiens (human)
Cellular locationNucleus: O60885
Total number of polymer chains1
Total formula weight16001.78
Authors
Zhu, J.-Y.,Ember, S.W.,Watts, C.,Schonbrunn, E. (deposition date: 2013-12-24, release date: 2014-03-05, Last modification date: 2023-09-20)
Primary citationEmber, S.W.,Zhu, J.Y.,Olesen, S.H.,Martin, M.P.,Becker, A.,Berndt, N.,Georg, G.I.,Schonbrunn, E.
Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors.
Acs Chem.Biol., 9:1160-1171, 2014
Cited by
PubMed: 24568369
DOI: 10.1021/cb500072z
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.34 Å)
Structure validation

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