4O5K

Structure of human DNA polymerase complexed with N7MG in the template base paired with incoming non-hydrolyzable CTP

Summary for 4O5K

• Entry DOI: 10.2210/pdb4o5k/pdb
• Related: 1BPX 3ISB 4O5C 4O5E
• Descriptor: DNA (5'-D(*CP*CP*GP*AP*CP*(FMG)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ... (8 entities in total)
• Functional Keywords: dna binding, polymerase fold, nucleotidyl transfer, dna, nucleus, transferase, lyase-dna complex, lyase/dna
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: P06746
• Total number of polymer chains: 4
• Total formula weight: 47241.41

Authors

Koag, M.C.,Lee, S. (deposition date: 2013-12-19, release date: 2014-07-02, Last modification date: 2024-02-28)

• Primary citation: Koag, M.C.,Kou, Y.,Ouzon-Shubeita, H.,Lee, S.; Transition-state destabilization reveals how human DNA polymerase beta proceeds across the chemically unstable lesion N7-methylguanine.; Nucleic Acids Res., 42:8755-8766, 2014; PubMed: 24966350; DOI: 10.1093/nar/gku554

Experimental method

X-RAY DIFFRACTION (2.058 Å)