4NWC

Crystal structure of the GluK3 ligand-binding domain (S1S2) in complex with the agonist (2S,4R)-4-(3-Methoxy-3-oxopropyl)glutamic acid at 2.01 A resolution.

Summary for 4NWC

Entry DOI	10.2210/pdb4nwc/pdb
Related	3S9E 4MH5
Descriptor	Glutamate receptor ionotropic, kainate 3, POTASSIUM ION, PHOSPHATE ION, ... (6 entities in total)
Functional Keywords	kainate receptor ligand-binding domain, agonist, ionotropic glutamate receptor, membrane protein, receptor-agonist complex, receptor/agonist
Biological source	Rattus norvegicus (brown rat,rat,rats) More
Cellular location	Cell membrane; Multi-pass membrane protein: P42264
Total number of polymer chains	1
Total formula weight	29534.29
Authors	Larsen, A.P.,Venskutonyte, R.,Frydenvang, K.,Gajhede, M.,Kastrup, J.S. (deposition date: 2013-12-06, release date: 2014-08-06, Last modification date: 2023-09-20)
Primary citation	Venskutonyte, R.,Larsen, A.P.,Frydenvang, K.,Gajhede, M.,Sagot, E.,Assaf, Z.,Gefflaut, T.,Pickering, D.S.,Bunch, L.,Kastrup, J.S. Molecular Recognition of Two 2,4-syn-Functionalized (S)-Glutamate Analogues by the Kainate Receptor GluK3 Ligand Binding Domain. Chemmedchem, 9:2254-2259, 2014 Cited by PubMed: 25044437 DOI: 10.1002/cmdc.201402204 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.012 Å)

Structure validation