4NWC

Crystal structure of the GluK3 ligand-binding domain (S1S2) in complex with the agonist (2S,4R)-4-(3-Methoxy-3-oxopropyl)glutamic acid at 2.01 A resolution.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Glutamate receptor ionotropic, kainate 3	polymer	258	29092.5	1	UniProt (P42264) Pfam (PF10613) Pfam (PF00060) In PDB	Rattus norvegicus (brown rat rat rats)	GluK3, Glutamate receptor 7, GluR-7, GluR7
2	A	POTASSIUM ION	non-polymer		39.1	2	Chemie (K)
3	A	PHOSPHATE ION	non-polymer		95.0	1	Chemie (PO4)
4	A	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
5	A	(2S,4R)-4-(3-Methoxy-3-oxopropyl) glutamic acid	non-polymer		233.2	1	Chemie (2QE)
6		water	water		18.0	230	Chemie (HOH)

Sequence modifications

A: 432 - 546 (UniProt: P42264)

PDB	External Database	Details
Gly 429	-	expression tag
Pro 430	-	expression tag
Gly 431	-	expression tag

A: 669 - 806 (UniProt: P42264)

PDB	External Database	Details
Gly 547	-	linker
Thr 548	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	29092.5
Non-Polymers*	Number of molecules	5
	Total formula weight	441.8
All*	Total formula weight	29534.3

*Water molecules are not included.