4NM7
Crystal structure of GSK-3/Axin complex bound to phosphorylated Wnt receptor LRP6 e-motif
Summary for 4NM7
Entry DOI | 10.2210/pdb4nm7/pdb |
Related | 4NM0 4NM3 4NM5 4NU1 |
Descriptor | GSK3B protein, Axin-1, Phosphorylated Wnt receptor LRP6 e-motif, ... (9 entities in total) |
Functional Keywords | wnt, lrp6, auto-inhibited, gsk-3, primed substrate, kinase, axin, phosphorylated wnt receptor lrp6 e-motif, transferase-peptide complex, transferase/peptide |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: O15169 |
Total number of polymer chains | 3 |
Total formula weight | 47543.19 |
Authors | Stamos, J.L.,Chu, M.L.-H.,Enos, M.D.,Shah, N.,Weis, W.I. (deposition date: 2013-11-14, release date: 2014-03-26, Last modification date: 2023-09-20) |
Primary citation | Stamos, J.L.,Chu, M.L.,Enos, M.D.,Shah, N.,Weis, W.I. Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6. Elife, 3:e01998-e01998, 2014 Cited by PubMed: 24642411PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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