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4NM0

Crystal structure of peptide inhibitor-free GSK-3/Axin complex

Summary for 4NM0
Entry DOI10.2210/pdb4nm0/pdb
Related4NM3 4NM5 4NM7 4NU1
DescriptorGlycogen synthase kinase-3 beta, Axin-1, GLYCEROL, ... (8 entities in total)
Functional Keywordswnt, lrp6, auto-inhibited, gsk-3, axin, kinase, primed substrate, transferase-peptide complex, transferase/peptide
Biological sourceHomo sapiens (human)
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Cellular locationCytoplasm: P49841 O15169
Total number of polymer chains2
Total formula weight48044.75
Authors
Chu, M.L.-H.,Stamos, J.L.,Enos, M.D.,Shah, N.,Weis, W.I. (deposition date: 2013-11-14, release date: 2014-03-26, Last modification date: 2023-09-20)
Primary citationStamos, J.L.,Chu, M.L.,Enos, M.D.,Shah, N.,Weis, W.I.
Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6.
Elife, 3:e01998-e01998, 2014
Cited by
PubMed: 24642411
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

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