4NJD

Structure of p21-activated kinase 4 with a novel inhibitor KY-04031

Summary for 4NJD

Entry DOI	10.2210/pdb4njd/pdb
Descriptor	Serine/threonine-protein kinase PAK 4, N-(1H-indazol-5-yl)-N'-[2-(1H-indol-3-yl)ethyl]-6-methoxy-1,3,5-triazine-2,4-diamine (3 entities in total)
Functional Keywords	kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: O96013
Total number of polymer chains	1
Total formula weight	33825.28
Authors	Park, S. (deposition date: 2013-11-09, release date: 2014-05-21, Last modification date: 2022-08-24)
Primary citation	Ryu, B.J.,Kim, S.,Min, B.,Kim, K.Y.,Lee, J.S.,Park, W.J.,Lee, H.,Kim, S.H.,Park, S. Discovery and the structural basis of a novel p21-activated kinase 4 inhibitor. Cancer Lett., 349:45-50, 2014 Cited by PubMed: 24704155 DOI: 10.1016/j.canlet.2014.03.024 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation