4JY6

Crystal structure of human Fab PGT123, a broadly reactive and potent HIV-1 neutralizing antibody

Summary for 4JY6

• Entry DOI: 10.2210/pdb4jy6/pdb
• Related: 4JY4 4JY5
• Descriptor: PGT123 light chain, PGT123 heavy chain, ZINC ION, ... (5 entities in total)
• Functional Keywords: broadly neutralizing antibody against hiv-1, hiv-1 env gp120 subunit, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 97064.46

Authors

Julien, J.-P.,Diwanji, D.C.,Burton, D.R.,Wilson, I.A. (deposition date: 2013-03-29, release date: 2013-05-08, Last modification date: 2023-09-20)

• Primary citation: Julien, J.P.,Sok, D.,Khayat, R.,Lee, J.H.,Doores, K.J.,Walker, L.M.,Ramos, A.,Diwanji, D.C.,Pejchal, R.,Cupo, A.,Katpally, U.,Depetris, R.S.,Stanfield, R.L.,McBride, R.,Marozsan, A.J.,Paulson, J.C.,Sanders, R.W.,Moore, J.P.,Burton, D.R.,Poignard, P.,Ward, A.B.,Wilson, I.A.; Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans.; Plos Pathog., 9:e1003342-e1003342, 2013; PubMed: 23658524; DOI: 10.1371/journal.ppat.1003342

Experimental method

X-RAY DIFFRACTION (2.5 Å)