4JY4

Crystal structure of human Fab PGT121, a broadly reactive and potent HIV-1 neutralizing antibody

Summary for 4JY4

• Entry DOI: 10.2210/pdb4jy4/pdb
• Related: 4JY5 4JY6
• Descriptor: PGT121 heavy chain, PGT121 light chain, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: broadly neutralizing antibody against hiv-1, hiv-1 env gp120 subunit, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 49734.01

Authors

Julien, J.-P.,Diwanji, D.C.,Burton, D.R.,Wilson, I.A. (deposition date: 2013-03-29, release date: 2013-05-15, Last modification date: 2023-09-20)

• Primary citation: Julien, J.P.,Sok, D.,Khayat, R.,Lee, J.H.,Doores, K.J.,Walker, L.M.,Ramos, A.,Diwanji, D.C.,Pejchal, R.,Cupo, A.,Katpally, U.,Depetris, R.S.,Stanfield, R.L.,McBride, R.,Marozsan, A.J.,Paulson, J.C.,Sanders, R.W.,Moore, J.P.,Burton, D.R.,Poignard, P.,Ward, A.B.,Wilson, I.A.; Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans.; Plos Pathog., 9:e1003342-e1003342, 2013; PubMed: 23658524; DOI: 10.1371/journal.ppat.1003342

Experimental method

X-RAY DIFFRACTION (2.8 Å)