4MJ4

Human iduronidase apo structure P21 form

Replaces:  4JXP

Summary for 4MJ4

• Entry DOI: 10.2210/pdb4mj4/pdb
• Related: 4KGJ 4KGL 4KH2 4MJ2
• Descriptor: Alpha-L-iduronidase, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... (6 entities in total)
• Functional Keywords: tim barrel, beta sandwich, fibronectin type iii, hydrolyze iduronic acids from the non-reducing ends of glycosaminoglycan, intracellular, lysosomal, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Lysosome: P35475
• Total number of polymer chains: 1
• Total formula weight: 74353.61

Authors

Bie, H.,Yin, J.,He, X.,Kermode, A.R.,Goddard-Borger, E.D.,Withers, S.G.,James, M.N.G. (deposition date: 2013-09-03, release date: 2013-09-18, Last modification date: 2023-09-20)

• Primary citation: Bie, H.,Yin, J.,He, X.,Kermode, A.R.,Goddard-Borger, E.D.,Withers, S.G.,James, M.N.; Insights into mucopolysaccharidosis I from the structure and action of alpha-L-iduronidase.; Nat.Chem.Biol., 9:739-745, 2013; PubMed: 24036510; DOI: 10.1038/nchembio.1357

Experimental method

X-RAY DIFFRACTION (2.172 Å)