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4KH2

Crystal structure of human alpha-L-iduronidase complex with 2-deoxy-2-fluoro-alpha-L-idopyranosyluronic acid fluoride

Summary for 4KH2
Entry DOI10.2210/pdb4kh2/pdb
Related4JXO 4JXP 4KGJ 4KGL
DescriptorAlpha-L-iduronidase, S,R MESO-TARTARIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
Functional Keywordsglycoside hydrolase family 39, tim barrel, beta sandwich, fibronectin iii domain, glycosaminoglycans, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationLysosome: P35475
Total number of polymer chains2
Total formula weight145151.97
Authors
Bie, H.,Yin, J.,He, X.,Kermode, A.R.,Goddard-Borger, E.D.,Withers, S.G.,James, M.N.G. (deposition date: 2013-04-29, release date: 2013-09-18, Last modification date: 2023-09-20)
Primary citationBie, H.,Yin, J.,He, X.,Kermode, A.R.,Goddard-Borger, E.D.,Withers, S.G.,James, M.N.
Insights into mucopolysaccharidosis I from the structure and action of alpha-L-iduronidase.
Nat.Chem.Biol., 9:739-745, 2013
Cited by
PubMed: 24036510
DOI: 10.1038/nchembio.1357
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.36 Å)
Structure validation

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