4KGJ

Crystal structure of human alpha-L-iduronidase complex with 5-fluoro-alpha-L-idopyranosyluronic acid fluoride

Summary for 4KGJ

Entry DOI	10.2210/pdb4kgj/pdb
Related	4JXO 4JXP 4KGL 4KH2
Descriptor	Alpha-L-iduronidase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
Functional Keywords	glycoside hydrolase family 39, tim barrel, beta sandwich, fibronectin iii domain, glycosaminoglycans, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Lysosome: P35475
Total number of polymer chains	2
Total formula weight	145276.59
Authors	Bie, H.,Yin, J.,He, X.,Kermode, A.R.,Goddard-Borger, E.D.,Withers, S.G.,James, M.N.G. (deposition date: 2013-04-29, release date: 2013-09-18, Last modification date: 2023-09-20)
Primary citation	Bie, H.,Yin, J.,He, X.,Kermode, A.R.,Goddard-Borger, E.D.,Withers, S.G.,James, M.N. Insights into mucopolysaccharidosis I from the structure and action of alpha-L-iduronidase. Nat.Chem.Biol., 9:739-745, 2013 Cited by PubMed: 24036510 DOI: 10.1038/nchembio.1357 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.99 Å)

Structure validation