4JIK

X-RAY Crystal structure of compound 22a (R)-2-(4-chlorophenyl)-8-(piperidin-3-ylamino)imidazo[1,2-c]pyrimidine-5-carboxamide bound to human chk1 kinase domain

Summary for 4JIK

Entry DOI	10.2210/pdb4jik/pdb
Descriptor	Serine/threonine-protein kinase Chk1, 2-(4-chlorophenyl)-8-[(3S)-piperidin-3-ylamino]imidazo[1,2-c]pyrimidine-5-carboxamide (3 entities in total)
Functional Keywords	kinase phosphatase transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Nucleus: O14757
Total number of polymer chains	1
Total formula weight	31826.07
Authors	Fischmann, T.O. (deposition date: 2013-03-06, release date: 2013-04-17, Last modification date: 2024-02-28)
Primary citation	Meng, Z.,Ciavarri, J.P.,McRiner, A.,Zhao, Y.,Zhao, L.,Reddy, P.A.,Zhang, X.,Fischmann, T.O.,Whitehurst, C.,Arshad Siddiqui, M. Potency switch between CHK1 and MK2: discovery of imidazo[1,2-a]pyrazine- and imidazo[1,2-c]pyrimidine-based kinase inhibitors. Bioorg.Med.Chem.Lett., 23:2863-2867, 2013 Cited by PubMed: 23587425 DOI: 10.1016/j.bmcl.2013.03.100 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation