Human TDG N140A mutant IN A COMPLEX WITH 5-carboxylcytosine (5caC)

Summary for 4JGC

DescriptorG/T mismatch-specific thymine DNA glycosylase (E.C.
Functional Keywords5-carboxylcytosine; thymine DNA glycosylase; DNA modification; DNA 5mC oxidation; epigenetic regulation, DNA demethylation, 5-carboxylcytosine, HYDROLASE-DNA complex,HYDROLASE/DNA
Biological sourceHomo sapiens (human)
Cellular locationNucleus Q13569
Total number of polymer chains3
Total molecular weight40303.05
Hashimoto, H.,Zhang, X.,Cheng, X. (deposition date: 2013-02-28, release date: 2013-05-29, modification date: 2013-07-03)
Primary citation
Hashimoto, H.,Zhang, X.,Cheng, X.
Activity and crystal structure of human thymine DNA glycosylase mutant N140A with 5-carboxylcytosine DNA at low pH.
Dna Repair, 12:535-540, 2013
PubMed: 23680598
DOI: 10.1016/j.dnarep.2013.04.003
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2931202.5%2.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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