4JGC

Human TDG N140A mutant IN A COMPLEX WITH 5-carboxylcytosine (5caC)

Summary for 4JGC

• Entry DOI: 10.2210/pdb4jgc/pdb
• Related: 4FNC
• Descriptor: G/T mismatch-specific thymine DNA glycosylase, oligonucleotide, oligonucleotide containing 5-carboxylcytosine, ... (5 entities in total)
• Functional Keywords: 5-carboxylcytosine; thymine dna glycosylase; dna modification; dna 5mc oxidation; epigenetic regulation, dna demethylation, 5-carboxylcytosine, hydrolase-dna complex, hydrolase/dna
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: Q13569
• Total number of polymer chains: 3
• Total formula weight: 40302.75

Authors

Hashimoto, H.,Zhang, X.,Cheng, X. (deposition date: 2013-02-28, release date: 2013-05-29, Last modification date: 2023-09-20)

• Primary citation: Hashimoto, H.,Zhang, X.,Cheng, X.; Activity and crystal structure of human thymine DNA glycosylase mutant N140A with 5-carboxylcytosine DNA at low pH.; Dna Repair, 12:535-540, 2013; PubMed: 23680598; DOI: 10.1016/j.dnarep.2013.04.003

Experimental method

X-RAY DIFFRACTION (2.582 Å)