4JGC

Human TDG N140A mutant IN A COMPLEX WITH 5-carboxylcytosine (5caC)

Summary for 4JGC

Related4FNC
DescriptorG/T mismatch-specific thymine DNA glycosylase (E.C.3.2.2.29)
Functional Keywords5-carboxylcytosine; thymine dna glycosylase; dna modification; dna 5mc oxidation; epigenetic regulation, dna demethylation, 5-carboxylcytosine, hydrolase-dna complex, hydrolase/dna
Biological sourceHomo sapiens (human)
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Cellular locationNucleus Q13569
Total number of polymer chains3
Total molecular weight40303.05
Authors
Hashimoto, H.,Zhang, X.,Cheng, X. (deposition date: 2013-02-28, release date: 2013-05-29, modification date: 2013-07-03)
Primary citation
Hashimoto, H.,Zhang, X.,Cheng, X.
Activity and crystal structure of human thymine DNA glycosylase mutant N140A with 5-carboxylcytosine DNA at low pH.
Dna Repair, 12:535-540, 2013
PubMed: 23680598
DOI: 10.1016/j.dnarep.2013.04.003
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.582 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2971202.5%4.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4jgc
no rotation
Molmil generated image of 4jgc
rotated about x axis by 90°
Molmil generated image of 4jgc
rotated about y axis by 90°
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