4FNC

Human TDG in a post-reactive complex with 5-hydroxymethyluracil (5hmU)

Summary for 4FNC

• Entry DOI: 10.2210/pdb4fnc/pdb
• Descriptor: G/T mismatch-specific thymine DNA glycosylase, DNA (28-MER), DNA (29-MER), ... (5 entities in total)
• Functional Keywords: base excision repair, hydrolase-dna complex, hydrolase/dna
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: Q13569
• Total number of polymer chains: 3
• Total formula weight: 40636.97

Authors

Hashimoto, H.,Hong, S.,Bhagwat, A.S.,Zhang, X.,Cheng, X. (deposition date: 2012-06-19, release date: 2012-09-19, Last modification date: 2023-09-13)

• Primary citation: Hashimoto, H.,Hong, S.,Bhagwat, A.S.,Zhang, X.,Cheng, X.; Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation.; Nucleic Acids Res., 40:10203-10214, 2012; PubMed: 22962365; DOI: 10.1093/nar/gks845

Experimental method

X-RAY DIFFRACTION (2.493 Å)