4JFF
Preservation of peptide specificity during TCR-MHC contact dominated affinity enhancement of a melanoma-specific TCR
Summary for 4JFF
Entry DOI | 10.2210/pdb4jff/pdb |
Related | 4JFD 4JFE 4JFH 4JFO 4JFP 4JFQ |
Descriptor | HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, Melanoma motif, ... (8 entities in total) |
Functional Keywords | hla, tcr, melanoma motif, immune system, high affinity |
Biological source | Homo sapiens (human) More |
Cellular location | Membrane; Single-pass type I membrane protein: P01892 Secreted: P61769 |
Total number of polymer chains | 5 |
Total formula weight | 95374.64 |
Authors | Rizkallah, P.J.,Cole, D.K.,Madura, F.,Sewell, A.K. (deposition date: 2013-02-28, release date: 2013-05-29, Last modification date: 2014-04-02) |
Primary citation | Madura, F.,Rizkallah, P.J.,Miles, K.M.,Holland, C.J.,Bulek, A.M.,Fuller, A.,Schauenburg, A.J.,Miles, J.J.,Liddy, N.,Sami, M.,Li, Y.,Hossain, M.,Baker, B.M.,Jakobsen, B.K.,Sewell, A.K.,Cole, D.K. T-cell receptor specificity maintained by altered thermodynamics. J.Biol.Chem., 288:18766-18775, 2013 Cited by PubMed: 23698002DOI: 10.1074/jbc.M113.464560 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.43 Å) |
Structure validation
Download full validation report