4JBV
Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1268
Summary for 4JBV
Entry DOI | 10.2210/pdb4jbv/pdb |
Related | 3SX9 3SXF 3T3V 3UPX 3UPZ 3V51 |
Descriptor | Calmodulin-domain protein kinase 1, 1-[(1-methylpiperidin-4-yl)methyl]-3-[6-(2-methylpropoxy)naphthalen-2-yl]pyrazolo[3,4-d]pyrimidin-4-amine (3 entities in total) |
Functional Keywords | serine/threonine protein kinase, transferase, calcium-binding, atp-binding, bumped kinase inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Toxoplasma gondii |
Total number of polymer chains | 1 |
Total formula weight | 55671.49 |
Authors | Merritt, E.A.,Larson, E.T. (deposition date: 2013-02-20, release date: 2014-03-19, Last modification date: 2024-02-28) |
Primary citation | Vidadala, R.S.,Ojo, K.K.,Johnson, S.M.,Zhang, Z.,Leonard, S.E.,Mitra, A.,Choi, R.,Reid, M.C.,Keyloun, K.R.,Fox, A.M.,Kennedy, M.,Silver-Brace, T.,Hume, J.C.,Kappe, S.,Verlinde, C.L.,Fan, E.,Merritt, E.A.,Van Voorhis, W.C.,Maly, D.J. Development of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes. Eur.J.Med.Chem., 74:562-573, 2014 Cited by PubMed: 24531197DOI: 10.1016/j.ejmech.2013.12.048 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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