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3UPZ

Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with bumpless BKI analog UW1243

Summary for 3UPZ
Entry DOI10.2210/pdb3upz/pdb
Related3UPX 3UQF 3UQG 3V51 3V5P 3V5T
DescriptorCalmodulin-domain protein kinase 1, 1-(piperidin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (3 entities in total)
Functional Keywordsserine/threonine protein kinase, calcium-binding, atp-binding, bumped kinase inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceToxoplasma gondii
Total number of polymer chains1
Total formula weight55459.20
Authors
Merritt, E.A.,Larson, E.T. (deposition date: 2011-11-18, release date: 2012-03-14, Last modification date: 2024-02-28)
Primary citationLarson, E.T.,Ojo, K.K.,Murphy, R.C.,Johnson, S.M.,Zhang, Z.,Kim, J.E.,Leibly, D.J.,Fox, A.M.,Reid, M.C.,Dale, E.J.,Perera, B.G.,Kim, J.,Hewitt, S.N.,Hol, W.G.,Verlinde, C.L.,Fan, E.,Van Voorhis, W.C.,Maly, D.J.,Merritt, E.A.
Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1.
J.Med.Chem., 55:2803-2810, 2012
Cited by
PubMed: 22369268
DOI: 10.1021/jm201725v
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

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