4J5W
Crystal Structure of the apo-PXR/RXRalpha LBD Heterotetramer Complex
Summary for 4J5W
Entry DOI | 10.2210/pdb4j5w/pdb |
Related | 4J5X |
Descriptor | Nuclear receptor subfamily 1 group I member 2, Nuclear receptor coactivator 1, Retinoic acid receptor RXR-alpha, Nuclear receptor coactivator 1, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | pregnane x receptor, retinoid x receptor alpha, ligand binding domain, nuclear receptor, alpha helical sandwich, unique intermolecular beta-sheet dimerization, xenobiotic sensing, upregulation of drug metabolism enzymes, retinoic acid-binding protein |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus : Q15788 Q15788 |
Total number of polymer chains | 4 |
Total formula weight | 135121.88 |
Authors | Wallace, B.D.,Betts, L.,Redinbo, M.R. (deposition date: 2013-02-10, release date: 2013-08-21, Last modification date: 2024-02-28) |
Primary citation | Wallace, B.D.,Betts, L.,Talmage, G.,Pollet, R.M.,Holman, N.S.,Redinbo, M.R. Structural and Functional Analysis of the Human Nuclear Xenobiotic Receptor PXR in Complex with RXRalpha. J.Mol.Biol., 425:2561-2577, 2013 Cited by PubMed: 23602807DOI: 10.1016/j.jmb.2013.04.012 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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