4J5X

Crystal Structure of the SR12813-bound PXR/RXRalpha LBD Heterotetramer Complex

Summary for 4J5X

Entry DOI	10.2210/pdb4j5x/pdb
Related	4J5W
Descriptor	Retinoic acid receptor RXR-alpha, Nuclear receptor coactivator 1, Nuclear receptor subfamily 1 group I member 2, Nuclear receptor coactivator 1, [2-(3,5-DI-TERT-BUTYL-4-HYDROXY-PHENYL)-1-(DIETHOXY-PHOSPHORYL)-VINYL]-PHOSPHONIC ACID DIETHLYL ESTER, ... (4 entities in total)
Functional Keywords	pregnane x receptor, retinoid x receptor alpha, ligand binding domain, nuclear receptor, sr12813, alpha helical sandwich, unique intermolecular beta-sheet dimerization, xenobiotic sensing, upregulation of drug metabolism enzymes, retinoic acid-binding protein
Biological source	Homo sapiens (human) More
Cellular location	Nucleus : Q15788 Q15788
Total number of polymer chains	4
Total formula weight	136082.34
Authors	Wallace, B.D.,Betts, L.,Redinbo, M.R. (deposition date: 2013-02-10, release date: 2013-08-21, Last modification date: 2024-02-28)
Primary citation	Wallace, B.D.,Betts, L.,Talmage, G.,Pollet, R.M.,Holman, N.S.,Redinbo, M.R. Structural and Functional Analysis of the Human Nuclear Xenobiotic Receptor PXR in Complex with RXRalpha. J.Mol.Biol., 425:2561-2577, 2013 Cited by PubMed: 23602807 DOI: 10.1016/j.jmb.2013.04.012 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation