4J5J
Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical Isolate PR20 in Complex with Amprenavir
Summary for 4J5J
Entry DOI | 10.2210/pdb4j5j/pdb |
Related | 4J54 4J55 |
Descriptor | Protease, CHLORIDE ION, {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER, ... (4 entities in total) |
Functional Keywords | multidrug resistant hiv-1 protease clinical isolate pr20, clinical inhibitor amprenavir, potent antiviral inhibitor grl-0519a, potent antiviral inhibitor grl-02031, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 (HIV-1) |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367 |
Total number of polymer chains | 2 |
Total formula weight | 22650.70 |
Authors | Shen, C.H.,Weber, I.T. (deposition date: 2013-02-08, release date: 2013-05-15, Last modification date: 2023-09-20) |
Primary citation | Agniswamy, J.,Shen, C.H.,Wang, Y.F.,Ghosh, A.K.,Rao, K.V.,Xu, C.X.,Sayer, J.M.,Louis, J.M.,Weber, I.T. Extreme Multidrug Resistant HIV-1 Protease with 20 Mutations Is Resistant to Novel Protease Inhibitors with P1'-Pyrrolidinone or P2-Tris-tetrahydrofuran. J.Med.Chem., 56:4017-4027, 2013 Cited by PubMed: 23590295DOI: 10.1021/jm400231v PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
Download full validation report