4IWO

Crystal structure and mechanism of activation of TBK1

Summary for 4IWO

Entry DOI	10.2210/pdb4iwo/pdb
Related	4IW0 4IWP 4IWQ
Descriptor	Serine/threonine-protein kinase TBK1, N-{3-[(5-cyclopropyl-2-{[3-(2-oxopyrrolidin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]propyl}cyclobutanecarboxamide (3 entities in total)
Functional Keywords	kinase, atp binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: Q9UHD2
Total number of polymer chains	1
Total formula weight	76371.40
Authors	Panne, D.,Larabi, A. (deposition date: 2013-01-24, release date: 2013-03-13, Last modification date: 2024-02-28)
Primary citation	Larabi, A.,Devos, J.M.,Ng, S.L.,Nanao, M.H.,Round, A.,Maniatis, T.,Panne, D. Crystal structure and mechanism of activation of TANK-binding kinase 1. Cell Rep, 3:734-746, 2013 Cited by PubMed: 23453971 DOI: 10.1016/j.celrep.2013.01.034 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.61 Å)

Structure validation