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4IWP

Crystal structure and mechanism of activation of TBK1

Summary for 4IWP
Entry DOI10.2210/pdb4iwp/pdb
Related4IW0 4IWO 4IWQ
DescriptorSerine/threonine-protein kinase TBK1, N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide (2 entities in total)
Functional Keywordskinase, atp binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: Q9UHD2
Total number of polymer chains1
Total formula weight76457.26
Authors
Panne, D.,Larabi, A. (deposition date: 2013-01-24, release date: 2013-03-13, Last modification date: 2024-02-28)
Primary citationLarabi, A.,Devos, J.M.,Ng, S.L.,Nanao, M.H.,Round, A.,Maniatis, T.,Panne, D.
Crystal structure and mechanism of activation of TANK-binding kinase 1.
Cell Rep, 3:734-746, 2013
Cited by
PubMed: 23453971
DOI: 10.1016/j.celrep.2013.01.034
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.065 Å)
Structure validation

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