4IRI

Auto-inhibited ERG Ets Domain-DNA Complex

Summary for 4IRI

• Entry DOI: 10.2210/pdb4iri/pdb
• Related: 4IRG 4IRH
• Descriptor: Transcriptional regulator ERG, DNA (5'-D(*GP*AP*CP*CP*GP*GP*AP*AP*GP*TP*GP*G)-3'), DNA (5'-D(*CP*CP*AP*CP*TP*TP*CP*CP*GP*GP*TP*C)-3'), ... (4 entities in total)
• Functional Keywords: winged helix-turn-helix, ets domain, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: P11308
• Total number of polymer chains: 3
• Total formula weight: 22198.50

Authors

Regan, M.C.,Horanyi, P.S.,Pryor, E.E.,Sarver, J.L.,Cafiso, D.S.,Bushweller, J.H. (deposition date: 2013-01-14, release date: 2013-07-31, Last modification date: 2024-02-28)

• Primary citation: Regan, M.C.,Horanyi, P.S.,Pryor, E.E.,Sarver, J.L.,Cafiso, D.S.,Bushweller, J.H.; Structural and dynamic studies of the transcription factor ERG reveal DNA binding is allosterically autoinhibited.; Proc.Natl.Acad.Sci.USA, 110:13374-13379, 2013; PubMed: 23898196; DOI: 10.1073/pnas.1301726110

Experimental method

X-RAY DIFFRACTION (2.77 Å)