4IRH
Auto-inhibited ERG Ets domain
Summary for 4IRH
| Entry DOI | 10.2210/pdb4irh/pdb |
| Related | 4IRG 4IRI |
| Descriptor | Transcriptional regulator ERG (2 entities in total) |
| Functional Keywords | winged helix-turn-helix, ets domain, dna binding protein |
| Biological source | Homo sapiens (human) |
| Cellular location | Nucleus: P11308 |
| Total number of polymer chains | 1 |
| Total formula weight | 15059.30 |
| Authors | Regan, M.C.,Horanyi, P.S.,Pryor, E.E.,Sarver, J.L.,Cafiso, D.S.,Bushweller, J.H. (deposition date: 2013-01-14, release date: 2013-07-31, Last modification date: 2013-08-28) |
| Primary citation | Regan, M.C.,Horanyi, P.S.,Pryor, E.E.,Sarver, J.L.,Cafiso, D.S.,Bushweller, J.H. Structural and dynamic studies of the transcription factor ERG reveal DNA binding is allosterically autoinhibited. Proc.Natl.Acad.Sci.USA, 110:13374-13379, 2013 Cited by PubMed: 23898196DOI: 10.1073/pnas.1301726110 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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