4IQU
Tdt core in complex with inhibitor (2Z,5E)-6-[4-(4-fluorobenzoyl)-1H-pyrrol-2-yl]-2-hydroxy-4-oxohexa-2,5-dienoic acid
Summary for 4IQU
Entry DOI | 10.2210/pdb4iqu/pdb |
Related | 4IQT 4IQV 4IQW |
Descriptor | DNA nucleotidylexotransferase, SODIUM ION, (2Z,5E)-6-[4-(4-fluorobenzoyl)-1H-pyrrol-2-yl]-2-hydroxy-4-oxohexa-2,5-dienoic acid, ... (4 entities in total) |
Functional Keywords | terminal transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Mus musculus (mouse) More |
Cellular location | Isoform TDT-S: Nucleus. Isoform TDT-L: Cytoplasm. Nucleus : P09838 |
Total number of polymer chains | 1 |
Total formula weight | 46056.29 |
Authors | Gouge, J.,Delarue, M. (deposition date: 2013-01-13, release date: 2013-09-04, Last modification date: 2024-03-13) |
Primary citation | Costi, R.,Cuzzucoli Crucitti, G.,Pescatori, L.,Messore, A.,Scipione, L.,Tortorella, S.,Amoroso, A.,Crespan, E.,Campiglia, P.,Maresca, B.,Porta, A.,Granata, I.,Novellino, E.,Gouge, J.,Delarue, M.,Maga, G.,Di Santo, R. New nucleotide-competitive non-nucleoside inhibitors of terminal deoxynucleotidyl transferase: discovery, characterization, and crystal structure in complex with the target. J.Med.Chem., 56:7431-7441, 2013 Cited by PubMed: 23968551DOI: 10.1021/jm4010187 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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