4IQW

Tdt core in complex with inhibitor (2Z,5E)-6-[4-(4-fluorobenzoyl)-1H-pyrrol-2-yl]-2-hydroxy-4-oxohexa-2,5-dienoic acid and ssDNA

Summary for 4IQW

• Entry DOI: 10.2210/pdb4iqw/pdb
• Related: 4IQT 4IQU 4IQV
• Descriptor: DNA nucleotidylexotransferase, 5'-D(*GP*CP*CP*G)-3', SODIUM ION, ... (5 entities in total)
• Functional Keywords: terminal transferase, transferase-transferase inhibitor-dna complex, transferase/transferase inhibitor/dna
• Biological source: Mus musculus (mouse); More
• Cellular location: Isoform TDT-S: Nucleus. Isoform TDT-L: Cytoplasm. Nucleus : P09838
• Total number of polymer chains: 2
• Total formula weight: 45172.82

Authors

Gouge, J.,Delarue, M. (deposition date: 2013-01-13, release date: 2013-09-04, Last modification date: 2023-09-20)

• Primary citation: Costi, R.,Cuzzucoli Crucitti, G.,Pescatori, L.,Messore, A.,Scipione, L.,Tortorella, S.,Amoroso, A.,Crespan, E.,Campiglia, P.,Maresca, B.,Porta, A.,Granata, I.,Novellino, E.,Gouge, J.,Delarue, M.,Maga, G.,Di Santo, R.; New nucleotide-competitive non-nucleoside inhibitors of terminal deoxynucleotidyl transferase: discovery, characterization, and crystal structure in complex with the target.; J.Med.Chem., 56:7431-7441, 2013; PubMed: 23968551; DOI: 10.1021/jm4010187

Experimental method

X-RAY DIFFRACTION (2.6 Å)