4IJQ
Human hypoxanthine-guanine phosphoribosyltransferase in complex with [(2-((Guanine-9H-yl)methyl)propane-1,3-diyl)bis(oxy)]bis(methylene))diphosphonic acid
Summary for 4IJQ
Entry DOI | 10.2210/pdb4ijq/pdb |
Related | 1BZY 1CJB 1HMP 3GEP |
Descriptor | Hypoxanthine-guanine phosphoribosyltransferase, [{2-[(guanine-9-yl)methyl]propane-1,3-diyl}bis(oxymethylene)]bis(phosphonic acid), SULFATE ION, ... (5 entities in total) |
Functional Keywords | gmp, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P00492 |
Total number of polymer chains | 4 |
Total formula weight | 103528.08 |
Authors | Guddat, L.W.,Keough, D.T.,Hockova, D. (deposition date: 2012-12-22, release date: 2013-03-27, Last modification date: 2024-03-20) |
Primary citation | Keough, D.T.,Spacek, P.,Hockova, D.,Tichy, T.,Vrbkova, S.,Slavetinska, L.,Janeba, Z.,Naesens, L.,Edstein, M.D.,Chavchich, M.,Wang, T.H.,Jersey, J.,Guddat, L.W. Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity J.Med.Chem., 56:2513-2526, 2013 Cited by PubMed: 23448281DOI: 10.1021/jm301893b PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.004 Å) |
Structure validation
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