3GEP

Human hypoxanthine guanine phosphoribosyltranserfase in complex with (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)guanine

Summary for 3GEP

Entry DOI	10.2210/pdb3gep/pdb
Related	1BZY 1D6N 1HMP 1Z7G
Descriptor	Hypoxanthine-guanine phosphoribosyltransferase, {[(1S)-2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-1-(hydroxymethyl)ethoxy]methyl}phosphonic acid (3 entities in total)
Functional Keywords	phosphoribosyltransferase, acyclic nucleoside phosphonate, purine salvage pathway, malarial chemotherapeutic, acetylation, cytoplasm, disease mutation, glycosyltransferase, gout, magnesium, metal-binding, purine salvage, transferase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: P00492
Total number of polymer chains	2
Total formula weight	49600.86
Authors	Guddat, L.W.,Keough, D.T.,Jersey, J. (deposition date: 2009-02-25, release date: 2009-08-18, Last modification date: 2023-11-01)
Primary citation	Keough, D.T.,Hockova, D.,Holy, A.,Naesens, L.M.,Skinner-Adams, T.S.,Jersey, J.,Guddat, L.W. Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics. J.Med.Chem., 52:4391-4399, 2009 Cited by PubMed: 19527031 DOI: 10.1021/jm900267n PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation