4IE1
Crystal structure of human Arginase-1 complexed with inhibitor 1h
Summary for 4IE1
Entry DOI | 10.2210/pdb4ie1/pdb |
Related | 1D3V 2AEB |
Descriptor | Arginase-1, [(5R)-5-amino-5-carboxy-8-hydroxyoctyl](trihydroxy)borate(1-), MANGANESE (II) ION, ... (4 entities in total) |
Functional Keywords | boron compounds, metalloenzyme, alpha/beta fold, hydrolase, arginine metabolism, manganese, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : P05089 |
Total number of polymer chains | 2 |
Total formula weight | 68567.59 |
Authors | Cousido-Siah, A.,Mitschler, A.,Ruiz, F.X.,Beckett, P.,Van Zandt, M.C.,Ji, M.K.,Whitehouse, D.,Ryder, T.,Jagdmann, E.,Andreoli, M.,Mazur, A.,Padmanilayam, M.,Schroeter, H.,Golebiowski, A.,Podjarny, A. (deposition date: 2012-12-13, release date: 2013-03-20, Last modification date: 2023-09-20) |
Primary citation | Golebiowski, A.,Paul Beckett, R.,Van Zandt, M.,Ji, M.K.,Whitehouse, D.,Ryder, T.R.,Jagdmann, E.,Andreoli, M.,Mazur, A.,Padmanilayam, M.,Cousido-Siah, A.,Mitschler, A.,Ruiz, F.X.,Podjarny, A.,Schroeter, H. 2-Substituted-2-amino-6-boronohexanoic acids as arginase inhibitors. Bioorg.Med.Chem.Lett., 23:2027-2030, 2013 Cited by PubMed: 23453840DOI: 10.1016/j.bmcl.2013.02.024 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.0006 Å) |
Structure validation
Download full validation report