4I03
Human MMP12 in complex with a PEG-linked bifunctional L-glutamate motif inhibitor
Summary for 4I03
Entry DOI | 10.2210/pdb4i03/pdb |
Related | 3TS4 3TSK 4EFS 4H30 4H49 |
Descriptor | Macrophage metalloelastase, ZINC ION, CALCIUM ION, ... (10 entities in total) |
Functional Keywords | selective carboxylate based mmp-12 bifunctional inhibitor, metzincin, zinc protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Secreted, extracellular space, extracellular matrix (Probable): P39900 |
Total number of polymer chains | 1 |
Total formula weight | 19807.11 |
Authors | Stura, E.A.,Vera, L.,Devel, L.,Cassar-Lajeunesse, E.,Dive, V. (deposition date: 2012-11-16, release date: 2013-04-24, Last modification date: 2024-02-28) |
Primary citation | Antoni, C.,Vera, L.,Devel, L.,Catalani, M.P.,Czarny, B.,Cassar-Lajeunesse, E.,Nuti, E.,Rossello, A.,Dive, V.,Stura, E.A. Crystallization of bi-functional ligand protein complexes. J.Struct.Biol., 182:246-254, 2013 Cited by PubMed: 23567804DOI: 10.1016/j.jsb.2013.03.015 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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