4HYF

Structural basis and SAR for OD 270, a lead stage 1,2,4-triazole based specific Tankyrase1/2 inhibitor

Summary for 4HYF

Entry DOI	10.2210/pdb4hyf/pdb
Related	3KR7 3KR8 3P0N 3U9Y 4HKI 4HKN
Descriptor	Tankyrase-2, NICOTINAMIDE, ZINC ION, ... (5 entities in total)
Functional Keywords	catalytic fragment, parp, adp-ribosylation, ank repeat, chromosomal protein, glycosyltransferase, phosphorylation, telomere, transferase, translocation, transport, wnt-signalling, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: Q9H2K2
Total number of polymer chains	3
Total formula weight	84051.77
Authors	Perdreau, H.,Ekblad, B.,Voronkov, A.,Holsworth, D.D.,Waaler, J.,Drewes, G.,Schueler, H.,Krauss, S.,Morth, J.P. (deposition date: 2012-11-13, release date: 2013-03-20, Last modification date: 2023-09-20)
Primary citation	Voronkov, A.,Holsworth, D.D.,Waaler, J.,Wilson, S.R.,Ekblad, B.,Perdreau-Dahl, H.,Dinh, H.,Drewes, G.,Hopf, C.,Morth, J.P.,Krauss, S. Structural Basis and SAR for G007-LK, a Lead Stage 1,2,4-Triazole Based Specific Tankyrase 1/2 Inhibitor. J.Med.Chem., 56:3012-3023, 2013 Cited by PubMed: 23473363 DOI: 10.1021/jm4000566 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation