4HWW
Crystal structure of human Arginase-1 complexed with inhibitor 9
Summary for 4HWW
Entry DOI | 10.2210/pdb4hww/pdb |
Related | 1D3V 2AEB 4HXQ 4HZE |
Descriptor | Arginase-1, [(5R)-5-amino-5-carboxy-7-(piperidin-1-yl)heptyl](trihydroxy)borate(1-), MANGANESE (II) ION, ... (4 entities in total) |
Functional Keywords | metalloenzyme, alpha/beta fold, hydrolase, arginine metabolism, manganese, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : P05089 |
Total number of polymer chains | 2 |
Total formula weight | 68673.80 |
Authors | Cousido-Siah, A.,Mitschler, A.,Ruiz, F.X.,Whitehouse, D.L.,Golebiowski, A.,Ji, M.,Zhang, M.,Beckett, P.,Sheeler, R.,Andreoli, M.,Conway, B.,Mahboubi, K.,Schroeter, H.,Van Zandt, M.C.,Podjarny, A. (deposition date: 2012-11-09, release date: 2013-03-20, Last modification date: 2023-09-20) |
Primary citation | Van Zandt, M.C.,Whitehouse, D.L.,Golebiowski, A.,Ji, M.K.,Zhang, M.,Beckett, R.P.,Jagdmann, G.E.,Ryder, T.R.,Sheeler, R.,Andreoli, M.,Conway, B.,Mahboubi, K.,D'Angelo, G.,Mitschler, A.,Cousido-Siah, A.,Ruiz, F.X.,Howard, E.I.,Podjarny, A.D.,Schroeter, H. Discovery of (R)-2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury. J.Med.Chem., 56:2568-2580, 2013 Cited by PubMed: 23472952DOI: 10.1021/jm400014c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.298 Å) |
Structure validation
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