4HUS

Crystal structure of streptogramin group A antibiotic acetyltransferase VatA from Staphylococcus aureus in complex with virginiamycin M1

Summary for 4HUS

• Entry DOI: 10.2210/pdb4hus/pdb
• Related: 4E8L 4HUR
• Descriptor: Virginiamycin A acetyltransferase, SULFATE ION, SODIUM ION, ... (9 entities in total)
• Functional Keywords: structural genomics, antibiotic resistance, center for structural genomics of infectious diseases (csgid), niaid, national institute of allergy and infectious diseases, xenobiotic acyltransferase (xat) family, hexapeptide repeat acyltransferase, streptogramin group a antibiotic acetyltransferase, streptogramin group a antibiotics, streptogramin a, virginiamycin m1, dalfopristin, acetyl coenzyme a, coenzyme a, intracellular, transferase-antibiotic complex, transferase/antibiotic
• Biological source: Staphylococcus aureus
• Total number of polymer chains: 3
• Total formula weight: 78345.22

Authors

Stogios, P.J.,Minasov, G.,Evdokimova, E.,Wawrzak, Z.,Yim, V.,Krishnamoorthy, M.,Di Leo, R.,Courvalin, P.,Savchenko, A.,Anderson, W.F.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2012-11-03, release date: 2012-11-21, Last modification date: 2023-09-20)

• Primary citation: Stogios, P.J.,Kuhn, M.L.,Evdokimova, E.,Courvalin, P.,Anderson, W.F.,Savchenko, A.; Potential for Reduction of Streptogramin A Resistance Revealed by Structural Analysis of Acetyltransferase VatA.; Antimicrob.Agents Chemother., 58:7083-7092, 2014; PubMed: 25223995; DOI: 10.1128/AAC.03743-14

Experimental method

X-RAY DIFFRACTION (2.36 Å)