4MYO

Crystal structure of streptogramin group A antibiotic acetyltransferase VatA from Staphylococcus aureus

Replaces:  4E8L

Summary for 4MYO

• Entry DOI: 10.2210/pdb4myo/pdb
• Related: 4HUR 4HUS
• Descriptor: Virginiamycin A acetyltransferase, MAGNESIUM ION, CHLORIDE ION, ... (5 entities in total)
• Functional Keywords: structural genomics, antibiotic resistance, center for structural genomics of infectious diseases, csgid, niaid, national institute of allergy and infectious diseases, left-handed beta helix domain, xenobiotic acyltransferase (xat) family, hexapeptide repeat acyltransferase, transferase, streptogramin group a antibiotics, streptogramin a, virginiamycin, dalfopristin, acetyl coenzyme a, coenzyme a, intracellular
• Biological source: Staphylococcus aureus
• Total number of polymer chains: 3
• Total formula weight: 73650.43

Authors

Stogios, P.J.,Minasov, G.,Dong, A.,Evdokimova, E.,Yim, V.,Krishnamoorthy, M.,Di Leo, R.,Courvalin, P.,Savchenko, A.,Anderson, W.F.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2013-09-27, release date: 2013-10-16, Last modification date: 2023-09-20)

• Primary citation: Stogios, P.J.,Kuhn, M.L.,Evdokimova, E.,Courvalin, P.,Anderson, W.F.,Savchenko, A.; Potential for Reduction of Streptogramin A Resistance Revealed by Structural Analysis of Acetyltransferase VatA.; Antimicrob.Agents Chemother., 58:7083-7092, 2014; PubMed: 25223995; DOI: 10.1128/AAC.03743-14

Experimental method

X-RAY DIFFRACTION (2.696 Å)