4H5E
Crystal structure of human FPPS in ternary complex with YS0470 and isopentenyl pyrophosphate
Summary for 4H5E
Entry DOI | 10.2210/pdb4h5e/pdb |
Related | 4DEM 4H5C 4H5D |
Descriptor | Farnesyl pyrophosphate synthase, [({4-[4-(propan-2-yloxy)phenyl]pyridin-2-yl}amino)methanediyl]bis(phosphonic acid), ISOPENTYL PYROPHOSPHATE, ... (5 entities in total) |
Functional Keywords | transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P14324 |
Total number of polymer chains | 1 |
Total formula weight | 43868.28 |
Authors | Park, J.,Lin, Y.-S.,Tsantrizos, Y.S.,Berghuis, A.M. (deposition date: 2012-09-18, release date: 2012-12-26, Last modification date: 2023-09-20) |
Primary citation | Park, J.,Lin, Y.S.,De Schutter, J.W.,Tsantrizos, Y.S.,Berghuis, A.M. Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme's active site closure. Bmc Struct.Biol., 12:32-32, 2012 Cited by PubMed: 23234314DOI: 10.1186/1472-6807-12-32 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.04 Å) |
Structure validation
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