4DEM

Crystal structure of human FPPS in complex with YS_04_70

Summary for 4DEM

Entry DOI	10.2210/pdb4dem/pdb
Descriptor	Farnesyl pyrophosphate synthase, [({4-[4-(propan-2-yloxy)phenyl]pyridin-2-yl}amino)methanediyl]bis(phosphonic acid), MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	mevalonate pathway, isoprene biosynthesis, cholesterol biosynthesis, bisphosphonate, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P14324
Total number of polymer chains	1
Total formula weight	43620.17
Authors	Park, J.,Lin, Y.-S.,Tsantrizos, Y.S.,Berghuis, A.M. (deposition date: 2012-01-20, release date: 2012-03-21, Last modification date: 2023-09-13)
Primary citation	Lin, Y.S.,Park, J.,De Schutter, J.W.,Huang, X.F.,Berghuis, A.M.,Sebag, M.,Tsantrizos, Y.S. Design and Synthesis of Active Site Inhibitors of the Human Farnesyl Pyrophosphate Synthase: Apoptosis and Inhibition of ERK Phosphorylation in Multiple Myeloma Cells. J.Med.Chem., 55:3201-3215, 2012 Cited by PubMed: 22390415 DOI: 10.1021/jm201657x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation