4H1N

Crystal Structure of P450 2B4 F297A Mutant in Complex with Anti-platelet Drug Clopidogrel

Summary for 4H1N

Entry DOI	10.2210/pdb4h1n/pdb
Related	1PO5 1SUO 2BDM 2Q6N 3G5N 3G93 3KW4 3ME6 3MVR 3R1A 3R1B
Descriptor	Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, 5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE, ... (6 entities in total)
Functional Keywords	p450, cytochrome p450 2b4, monooxygenase, oxidoreductase
Biological source	Oryctolagus cuniculus (European rabbit,Japanese white rabbit,domestic rabbit,rabbits)
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein: P00178
Total number of polymer chains	1
Total formula weight	57025.51
Authors	Shah, M.B.,Jang, H.H.,Stout, C.D.,Halpert, J.R. (deposition date: 2012-09-10, release date: 2013-01-16, Last modification date: 2023-09-13)
Primary citation	Shah, M.B.,Jang, H.H.,Zhang, Q.,David Stout, C.,Halpert, J.R. X-ray crystal structure of the cytochrome P450 2B4 active site mutant F297A in complex with clopidogrel: Insights into compensatory rearrangements of the binding pocket. Arch.Biochem.Biophys., 530:64-72, 2013 Cited by PubMed: 23296089 DOI: 10.1016/j.abb.2012.12.016 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.99 Å)

Structure validation