4GS9
Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains in complex with an inactive benzoxadiazole antagonist
Summary for 4GS9
Entry DOI | 10.2210/pdb4gs9/pdb |
Related | 1P97 1X0O 2A24 2B02 3F1N 3F1O 3F1P 3H7W 3H82 4GHI |
Descriptor | Endothelial PAS domain-containing protein 1, Aryl hydrocarbon receptor nuclear translocator, N-(3-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine, ... (5 entities in total) |
Functional Keywords | pas fold, transcription, protein-protein interactions, nucleus |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus : Q99814 P27540 |
Total number of polymer chains | 2 |
Total formula weight | 28426.04 |
Authors | Scheuermann, T.H.,Gardner, K.H. (deposition date: 2012-08-27, release date: 2013-04-03, Last modification date: 2023-09-13) |
Primary citation | Rogers, J.L.,Bayeh, L.,Scheuermann, T.H.,Longgood, J.,Key, J.,Naidoo, J.,Melito, L.,Shokri, C.,Frantz, D.E.,Bruick, R.K.,Gardner, K.H.,Macmillan, J.B.,Tambar, U.K. Development of Inhibitors of the PAS-B Domain of the HIF-2 alpha Transcription Factor J.Med.Chem., 56:1739-1747, 2013 Cited by PubMed: 23363003DOI: 10.1021/jm301847z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.72 Å) |
Structure validation
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