4GCS

Crystal Structure of E. coli OmpF porin in complex with Ertapenem

Summary for 4GCS

• Entry DOI: 10.2210/pdb4gcs/pdb
• Related: 4GCP 4GCQ
• Descriptor: Outer membrane protein F, (4R,5S)-3-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid (3 entities in total)
• Functional Keywords: beta-barrel, protein-drug complex, trimer, non-specific channel, ertapenem binding, outer membrane, membrane protein-antibiotic complex, membrane protein/antibiotic
• Biological source: Escherichia coli
• Cellular location: Cell outer membrane; Multi-pass membrane protein: P02931
• Total number of polymer chains: 2
• Total formula weight: 75297.66

Authors

Ziervogel, B.K.,Roux, B. (deposition date: 2012-07-30, release date: 2012-12-19, Last modification date: 2024-02-28)

• Primary citation: Ziervogel, B.K.,Roux, B.; The Binding of Antibiotics in OmpF Porin.; Structure, 21:76-87, 2013; PubMed: 23201272; DOI: 10.1016/j.str.2012.10.014

Experimental method

X-RAY DIFFRACTION (1.87 Å)