4G9C
Human B-Raf Kinase Domain bound to a Type II Pyrazolopyridine Inhibitor
Summary for 4G9C
Entry DOI | 10.2210/pdb4g9c/pdb |
Related | 4G9R |
Descriptor | Serine/threonine-protein kinase B-raf, 3-{[3-(2-cyanopropan-2-yl)benzoyl]amino}-2,6-difluoro-N-(3-methoxy-2H-pyrazolo[3,4-b]pyridin-5-yl)benzamide (2 entities in total) |
Functional Keywords | dfg-out, inhibitor, type ii, transferase, kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus (By similarity): P15056 |
Total number of polymer chains | 2 |
Total formula weight | 71416.19 |
Authors | Voegtli, W.C.,Sturgis, H.L. (deposition date: 2012-07-23, release date: 2012-11-14, Last modification date: 2024-02-28) |
Primary citation | Wenglowsky, S.,Moreno, D.,Laird, E.R.,Gloor, S.L.,Ren, L.,Risom, T.,Rudolph, J.,Sturgis, H.L.,Voegtli, W.C. Pyrazolopyridine inhibitors of B-Raf(V600E). Part 4: Rational design and kinase selectivity profile of cell potent type II inhibitors. Bioorg.Med.Chem.Lett., 22:6237-6241, 2012 Cited by PubMed: 22954737DOI: 10.1016/j.bmcl.2012.08.007 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.5 Å) |
Structure validation
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