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4G9R

B-Raf V600E Kinase Domain Bound to a Type II Dihydroquinazoline Inhibitor

Summary for 4G9R
Entry DOI10.2210/pdb4g9r/pdb
Related4G9C
DescriptorSerine/threonine-protein kinase B-raf, 3-(2-cyanopropan-2-yl)-N-{4-methyl-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}benzamide (2 entities in total)
Functional Keywordsinhibitor, type ii, transferase, kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationNucleus (By similarity): P15056
Total number of polymer chains2
Total formula weight71398.27
Authors
Voegtli, W.C.,Sturgis, H.L. (deposition date: 2012-07-24, release date: 2012-11-14, Last modification date: 2024-02-28)
Primary citationWenglowsky, S.,Moreno, D.,Laird, E.R.,Gloor, S.L.,Ren, L.,Risom, T.,Rudolph, J.,Sturgis, H.L.,Voegtli, W.C.
Pyrazolopyridine inhibitors of B-Raf(V600E). Part 4: Rational design and kinase selectivity profile of cell potent type II inhibitors.
Bioorg.Med.Chem.Lett., 22:6237-6241, 2012
Cited by
PubMed: 22954737
DOI: 10.1016/j.bmcl.2012.08.007
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.2 Å)
Structure validation

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