4G5P
Crystal structure of EGFR kinase T790M in complex with BIBW2992
Summary for 4G5P
Entry DOI | 10.2210/pdb4g5p/pdb |
Related | 4G5J |
Descriptor | Epidermal growth factor receptor, N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3S)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide (3 entities in total) |
Functional Keywords | egf receptor kinase mutant t790m, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533 |
Total number of polymer chains | 2 |
Total formula weight | 75707.05 |
Authors | Solca, F.,Dahl, G.,Zoephel, A.,Bader, G.,Sanderson, M.,Klein, C.,Kraemer, O.,Himmelsbach, F.,Haaksma, E.,Adolf, G.R. (deposition date: 2012-07-18, release date: 2012-08-29, Last modification date: 2012-10-31) |
Primary citation | Solca, F.,Dahl, G.,Zoephel, A.,Bader, G.,Sanderson, M.,Klein, C.,Kraemer, O.,Himmelsbach, F.,Haaksma, E.,Adolf, G.R. Target Binding Properties and Cellular Activity of Afatinib (BIBW 2992), an Irreversible ErbB Family Blocker. J.Pharmacol.Exp.Ther., 343:342-350, 2012 Cited by PubMed: 22888144DOI: 10.1124/jpet.112.197756 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.17 Å) |
Structure validation
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