4G5J

Crystal structure of EGFR kinase in complex with BIBW2992

Summary for 4G5J

• Entry DOI: 10.2210/pdb4g5j/pdb
• Related: 4G5P
• Descriptor: Epidermal growth factor receptor, N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3S)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide, (2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3S)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide, ... (4 entities in total)
• Functional Keywords: protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
• Total number of polymer chains: 1
• Total formula weight: 39039.29

Authors

Solca, F.,Dahl, G.,Zoephel, A.,Bader, G.,Sanderson, M.,Klein, C.,Kraemer, O.,Himmelsbach, F.,Haaksma, E.,Adolf, G.R. (deposition date: 2012-07-18, release date: 2012-08-29, Last modification date: 2012-10-31)

• Primary citation: Solca, F.,Dahl, G.,Zoephel, A.,Bader, G.,Sanderson, M.,Klein, C.,Kraemer, O.,Himmelsbach, F.,Haaksma, E.,Adolf, G.R.; Target Binding Properties and Cellular Activity of Afatinib (BIBW 2992), an Irreversible ErbB Family Blocker.; J.Pharmacol.Exp.Ther., 343:342-350, 2012; PubMed: 22888144; DOI: 10.1124/jpet.112.197756

Experimental method

X-RAY DIFFRACTION (2.8 Å)