4G5F
Pantothenate synthetase in complex with racemate (2S)-2,3-DIHYDRO-1,4-BENZODIOXINE-2-CARBOXYLIC ACID and (2R)-2,3-DIHYDRO-1,4-BENZODIOXINE-2-CARBOXYLIC ACID
Summary for 4G5F
Entry DOI | 10.2210/pdb4g5f/pdb |
Related | 4DDH 4DDK 4DDM 4EF6 4EFK 4FZJ |
Descriptor | Pantothenate synthetase, GLYCEROL, (2S)-2,3-dihydro-1,4-benzodioxine-2-carboxylic acid, ... (7 entities in total) |
Functional Keywords | alpha beta 3-layer(aba) sandwich rossmann fold, ligase, atp binding pantoate binding beta-alanine binding, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Mycobacterium tuberculosis |
Cellular location | Cytoplasm (Potential): P0A5R0 |
Total number of polymer chains | 2 |
Total formula weight | 66355.81 |
Authors | Silvestre, H.L.,Blundell, T.L.,Abell, C.,Ciulli, A. (deposition date: 2012-07-17, release date: 2013-07-17, Last modification date: 2023-09-13) |
Primary citation | Silvestre, H.L.,Blundell, T.L.,Abell, C.,Ciulli, A. Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery. Proc.Natl.Acad.Sci.USA, 110:12984-12989, 2013 Cited by PubMed: 23872845DOI: 10.1073/pnas.1304045110 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.33 Å) |
Structure validation
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