4FZJ
Pantothenate synthetase in complex with 1,3-DIMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID
Summary for 4FZJ
Entry DOI | 10.2210/pdb4fzj/pdb |
Related | 4DDH 4DDK 4DDM 4DE5 4EF6 4EFK |
Descriptor | Pantothenate synthetase, ETHANOL, 1,2-ETHANEDIOL, ... (6 entities in total) |
Functional Keywords | rossmann fold, atp + (r)-pantoate + beta-alanine, citoplasm, ligase |
Biological source | Mycobacterium tuberculosis |
Cellular location | Cytoplasm (Potential): P0A5R0 |
Total number of polymer chains | 2 |
Total formula weight | 64672.17 |
Authors | Silvestre, H.L.,Blundell, T.L.,Abell, C.,Ciulli, A. (deposition date: 2012-07-06, release date: 2013-06-26, Last modification date: 2024-02-28) |
Primary citation | Silvestre, H.L.,Blundell, T.L.,Abell, C.,Ciulli, A. Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery. Proc.Natl.Acad.Sci.USA, 110:12984-12989, 2013 Cited by PubMed: 23872845DOI: 10.1073/pnas.1304045110 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.63 Å) |
Structure validation
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