4G3F

Crystal structure of murine NF-kappaB inducing kinase (NIK) bound to a 2-(aminothiazoly)phenol (cmp2)

Summary for 4G3F

• Entry DOI: 10.2210/pdb4g3f/pdb
• Related: 4G3C 4G3D 4G3E 4G3G
• Descriptor: NF-kappa-beta-inducing kinase, 3-{2-[(5-fluoro-2-hydroxyphenyl)amino]-1,3-thiazol-4-yl}benzonitrile (3 entities in total)
• Functional Keywords: non-rd kinase, protein serine/threonine kinase, nf-kappab, structure-based drug design, map3k14, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Mus musculus (mouse)
• Cellular location: Cytoplasm: Q9WUL6
• Total number of polymer chains: 1
• Total formula weight: 37290.92

Authors

Hymowitz, S.G.,de Leon-Boenig, G. (deposition date: 2012-07-13, release date: 2012-08-08, Last modification date: 2024-02-28)

• Primary citation: de Leon-Boenig, G.,Bowman, K.K.,Feng, J.A.,Crawford, T.,Everett, C.,Franke, Y.,Oh, A.,Stanley, M.,Staben, S.T.,Starovasnik, M.A.,Wallweber, H.J.,Wu, J.,Wu, L.C.,Johnson, A.R.,Hymowitz, S.G.; The crystal structure of the catalytic domain of the NF-kappaB inducing kinase reveals a narrow but flexible active site.; Structure, 20:1704-1714, 2012; PubMed: 22921830; DOI: 10.1016/j.str.2012.07.013

Experimental method

X-RAY DIFFRACTION (1.642 Å)